ACEI and ARB can Cause Increase of Creatinine
Creatinine is produced through muscle metabolism and is discharged out of the body through the filtration of the kidneys; therefore it is a reliable indicator of kidney functions and other health issues.
The measuring unit of creatinine in the United States is in mg/dl, whereas, in Canada, Australia and a few European countries, μmol/litre may be used. 1 mg/dl of creatinine is 88.4 μmol/l.
The typical human reference ranges for serum creatinine are 0.5 to 1.0 mg/dl (about 45-90 μmol/l) for women and 0.7 to 1.2 mg/dl (60-110 μmol/L) for men. While a baseline serum creatinine of 2.0 mg/dl (150 μmol/l) may indicate normal kidney function in a male body builder, a serum creatinine of 1.2 mg/dl (110 μmol/l) can indicate significant renal disease in an elderly female.
I suppose that the most common reasons for developing raised creatinine levels will be when the filtration mechanism becomes gradually damaged by long-term raised blood pressure or blood sugar.
Creatinine levels can be increased when ACE inhibitors (ACEI) or angiotensin II receptor antagonists (or angiotensin receptor blockers, ARBs) are taken. Using both ACEI and ARB concomitantly will increase creatinine levels to a greater degree than either of the two drugs would individually. An increase of <30% will be expected with ACEI or ARB use. Therefore it is important and necessary to have regular tests to have close monitoring of the creatinine level and kidney functions.