Polycystic Kidney Disease Causes

What causes PKD?
The pathological changes of PKD are: autosome dominant inheritance transformed the phenotype of the epithelial cells in nephridial tubule into epithelial cells in cyst wall. Constantly sac liquid made the cysts become bigger and bigger, and then the normal structure in the kidney be replaced by the cysts, the parclose function of glomerulus decreases as well as the concentration, reabsorption, regulation function in nephridial tubule. Therefore, we can find some signs such as protein and occult blood when we do routine urinalysis, and PKD is in fact a kind of Renal Tubular Epithelial Cell Disease.
What are the properties of PKD?
A typical character of PKD is its tendency of family gathering. As long as one of the parents has PKD, each child of them has 50% rate to have it. (But if you have examined that it isn’t this disease, then you need not worry about its transforming to this trend). Then how does PKD come occur? PKD is an inheritable disease which belongs to autosome dominant inheritance and develops progressively. Most of the patients are attacked in adulthood, and part of them may be accompanied by cysts and stones in liver.
Another remarkable character of PKD is abnormal proliferation in epithelial cells of nephridial tubule. When the phenotypes of the epithelial cells are transformed into epithelial cells in cyst wall, the secreted liquid by them will increase progressively while there is no way of excretion. With time passing by, the sac liquid gathers more and more, causing the volume of cysts increases and the capsular pressure rises as well as the surface tension of cysts. At this time, some sensitive patients may feel uncomfortable or acid swollerpain in their waist part. They may feel pain if part of the cysts is infected.