2013年1月1日星期二

ADPKD, Chinese Medicines and Daily Cares


Illness description: My wife has ADPKD and she has begun dialysis since 2010. Her GFR at 2010 is about 16ml/min. Now my daughter is found have polycystic kidney disease. Is there any treatment or medicines for curing the disease?
The following are the medicines that my wife take:
(1) Prazosin Hydrochloride - 2mg. = 2+2+2+2. (2) Nifedipine - 2mg. = 2+2+2. (3) Atenolol BP – 50 = 1+0+1. (4) Losartan Potassium – 50 = 1+0+1. (5) Furosemide BP - 40mg. = 4+4+0. (6) Diphenyl Hydantoin - 100mg. = 0+0+2. (7) Levosalbutamol - 1mg. = 1+0+1. (8) Bambuterol Hydrochloride - 10mg. = 0+0 +1 (9) Desloratadine inn - 5mg. = 0+0+1. (10) Calcium Acetate - 667mg. = 1+0+1. (11) Domperidone - 10mg. = 1+1+1. (12) Rabeprazole Sodium IP 20mg. = 1+1+1. (13) Atorvastatin - 20mg. = 0+1+1. (14) Multivit = 0+0+1.(15) Clonozapam BP*– 0.5mg. = 0+0+1.
Illness analysis: To be honest, your wife’s condition is severe. Her kidney cysts are very large and the big cysts have caused damage to her renal tissues. Her GFR was about 16ml/min at 2010. It means that her kidney function was about 16% at that time.
Besides, among her medicines, the first four medicines are taken for controlling blood pressure. Others are for relieving various symptoms, such as vomiting, nausea, difficult breathing, etc. That is to say, no medicine can shrink her cysts or repair the damaged renal tissues. Therefore, the medicines she takes don’t treat her PKD but just relieve her symptoms.
Also, the levels of urea and creatinine are high. This is because the damaged kidneys cannot filter metabolic wastes in the blood normally. A healthy kidney mainly has three functions, namely filtration function, secretion function as well as regulating electrolyte and water in blood. Due to the excess pressure from big cysts to renal tissues, the kidneys are damaged and kidney functions are impaired.
Of course, her condition is not too severe to be handled with. She still has chance to get much improvement by receiving Chinese herb medicine. As you mentioned, she has no anemia, which indicates that her kidneys can produce moderate EPO. She has no itching problem, which shows that her blood phosphorus is not very high and eletrolyte is relatively balanced.
At present, your wife faces two problems. One is the increasing cysts; the other is the damaged renal tissues, or rather renal functional cells. Chinese herb medicine is mainly used to shrink and restrain the cyst and improve kidney function.
As to your daughter, she is at the early stage. The most important thing for her is to restrain the growth of her cysts. The doctor doesn’t give her any medicine. This is because there is no effective medicine in western medical science to prevent kidney function impairment. In western medicine, only when PKD patients have symptoms, for example, hypertension, the doctor will give them anti-hypertensive medicine to relieve such problem. However, Chinese medical science is different. Chinese herb medicine can restrain the growth of the cysts so as to protect kidney function.
Chinese herb medicine
Chinese medicines are mainly composed of herbs, insects and animal parts. One prescription contains many herbs. Each herb has its own effect, and all of them interact with each other, producing other effects. The prescription for PKD includes about 20 Chinese medicines, such as Szechwan Lovage Rhizome, Tetradium ruticarpum, ganoderma, Cordyceps, etc.
It is not a surgery but a conservative external application therapy. Chinese herb medicines applied to treat PKD are superfinely shattered and then packaged in sacks. After soaked and heated for some time, two sacks filled with medicines are attached to patient’s renal region. With the help of an osmosis device, ingredients of herb medicines can permeate into renal lesion via acupoints and channels (a term in Chinese medical science)
Chinese herb medicine also cannot change the abnormal genes in patients with PKD. It has some advantages over western medicine, because apart from relieving symptoms like western medicine does, Chinese medicine also can improve ischemia and anoxia of renal tissues and repair the damaged renal functional cells as well as doing with the increasing kidney cysts. Speaking in detailedly, Chinese herb medicine takes effect mainly from the follow aspects.
1) Some herb medicines have effects of anti-inflammation, anti-coagulation as well as preventing blood viscosity, dilating blood vessels and degrading extra cellular matrixes. Therefore, Chinese herb medicine can improve blood circulation and thereby improve ischemia and anoxia of renal tissues. As you know, ischemia and anoxia are the key factors of renal fibrosis.
2) Chinese herbs can supply vitamin, micronutrients, organic acid and other nutrients for repairing the damaged renal functional cells. Also, some herbs stimulate DNA replication of the damaged cells, thus speeding up the progress of cells’ self-repair.
3) Chinese herb medicine deals with kidneys cysts mainly through increasing the permeability of cyst walls and restraining secretion of cyst fluids. Compared with removing cysts by surgery, Chinese herb medicine is relatively slow, but it can deal with both small and big cysts and won’t cause any damage to the kidneys issues.
Besides, here are some tips for your wife and daughter.
1) Please avoid factors that cause a cold or infection. Either of them can aggravate illness condition.
2) In my mind, Bengali people like dancing and are able to dance beautifully. I guess that Rasha, as a teenager girl is also good at dancing. In this case, I advise her not to dance excessively, or rather not to do strenuous exercise, especially contacting sports,such as basketball, volleyball,etc.
3) Avoid wearing the belt tightly. This may lay pressure on cysts.
4) Female with PKD is easy to develop urinary tract infection. To prevent UTI, female should use shower instead of bath in a tub, and pass urine timely as well as cleaning vulva often.
5) Follow healthy diet and avoid alcohol, tobacco and spicy foods.

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